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Desloratadine
Clinical data
Trade namesClarinex (US), Aerius, Dasselta, Deslordis (EU), others
AHFS/Drugs.comMonograph
MedlinePlusa602002
License dataEU  EMA:  by INN, US   FDA: Desloratadine
Pregnancy categoryAU: B1 US: C (Risk not ruled out)
Routes of administrationOral (tablets, solution)
ATC codeR06AX27 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) CA : OTC UK: POM (Prescription only) US: 邃-only
Pharmacokinetic data
BioavailabilityRapidly absorbed
Protein binding83 to 87%
MetabolismUGT2B10, CYP2C8
Metabolites3-Hydroxydesloratadine
Onset of actionwithin 1 hour
Elimination half-life27 hours
Duration of actionup to 24 hours
Excretion40% as conjugated metabolites into urine Similar amount into the feces

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