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Duloxetine
Clinical data
Trade namesCymbalta, many others [1]
AHFS/Drugs.comMonograph
MedlinePlusa604030
License dataEU  EMA:  by INN, US   FDA: duloxetine
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationOral
ATC codeN06AX21 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : 邃-only UK: POM (Prescription only) US: 邃-only
Pharmacokinetic data
Bioavailability~ 50% (32% to 80%)
Protein binding~ 95%
MetabolismLiver, two P450 isozymes, CYP2D6 and CYP1A2
Elimination half-life12.1 hours
Excretion70% in urine, 20% in feces

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