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    It is practically insoluble in water, sparingly soluble in ether and very soluble in polyethylene glycolethanol and chloroform. In general, the in vitro activity of clotrimazole corresponds to that of tolnaftate and griseofulvin against the mycelia of dermatophytes Trichophyton, Microsporum, and Epidermophytonand to that of the polyenes amphotericin B and nystatin against budding fungi Candida.

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    • Protein c deficiency and coumadin ‒ Warfarin (fusidic) 1 mg, warfarin should immediately be discontinued and affected individuals should be treated with vitamin k and therapeutic doses of heparin.. Warfarin should be taken approximately 30-60 minutes before intended sexual activity and on an empty stomach.
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